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This paper, Comparative Cost-Effectiveness Analysis to Inform Policy in Developing Countries: A General Framework with Applications for Education, looks at how comparative cost-effectiveness analyses can help inform policy in developing countries and the underlying methodological assumptions necessary for performing this kind of analysis. Examples are drawn from the education field to illustrate key issues and focus on specific applications to education. This paper aims to contribute to the development of a more standard methodology for cost-effectiveness analyses and a better understanding of how these analyses can be created and used.