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The Support Center for Girls in Difficult Situations’ (CAJEFED) operates in in Guéckédou, Guinea, near the borders with Liberia and Sierra Leone. The aim of this case study is to explore the effects of CAJEFED’s intervention on adolescent girls’ education and look at lessons learned, challenges, and enabling factors for replicating the model. The case study research methodology consisted of interviewing key project stakeholders (including adolescent girl beneficiaries; CAJEFED staff members; school, healthcare, and welfare service authorities; international NGOs; and donor organizations) holding a workshop to debate study findings, and sharing knowledge and experience with implementers of similar projects.